Targets of DAF-16 involved in Caenorhabditis elegans adult longevity and dauer formation.
Exp Gerontol
; 41(10): 922-7, 2006 Oct.
Article
en En
| MEDLINE
| ID: mdl-17055208
ABSTRACT
The Forkhead Box O transcription factor DAF-16 regulates genes affecting dauer larva formation and adult life span. Expression profiling and genome-wide searches for DAF-16 binding sites in gene regulatory regions have identified thousands of potential DAF-16 targets. Some of these genes have been shown to alter longevity when their expression is attenuated by RNAi treatment. DAF-16 also associates with other transcription factors, allowing combinatorial modulation of gene expression. Although extensive descriptions of the gene network regulated by DAF-16 have been attempted, there remain many gaps in the understanding of how DAF-16 regulates dauer formation and longevity.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Envejecimiento
/
Caenorhabditis elegans
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Proteínas de Caenorhabditis elegans
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Factores de Transcripción Forkhead
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Exp Gerontol
Año:
2006
Tipo del documento:
Article