Determination of malondialdehyde, reduced glutathione levels and APOE4 allele frequency in late-onset Alzheimer's disease in Denizli, Turkey.
Clin Biochem
; 40(3-4): 172-6, 2007 Feb.
Article
en En
| MEDLINE
| ID: mdl-17069783
ABSTRACT
OBJECTIVES:
The aim of the present study was to determine the Apolipoprotein E (APOE) 4 allele frequency of patients with late-onset Alzheimer's disease (AD) and to determine the effects of oxidant-antioxidant balance on AD. DESIGN ANDMETHODS:
PCR-RFLP was undertaken in 62 cases with AD and 56 aged-matched controls. Activities of reduced glutathione (GSH) and malondialdehyde (MDA) concentration were measured in same groups.RESULTS:
Patients with at least one E4 allele genotype were significantly different in patients with AD (21%) than controls (9%) (p=0.01). Serum MDA levels were significantly different between AD patients and Control group (p=0.0001). There was no significant difference in serum GSH levels between AD patients and C groups.CONCLUSION:
These results confirmed that the APOE4 allele occurs frequently in late onset AD compared with normal controls. Also elevated MDA levels are likely an essential factor in the pathogenesis and neuronal damage of AD.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Apolipoproteína E4
/
Enfermedad de Alzheimer
/
Glutatión
/
Malondialdehído
Límite:
Aged
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Clin Biochem
Año:
2007
Tipo del documento:
Article
País de afiliación:
Turquía