Spontaneous splenic haematoma in a multiple myeloma patient receiving pegfilgrastim support.
Clin Lab Haematol
; 28(6): 416-8, 2006 Dec.
Article
en En
| MEDLINE
| ID: mdl-17105496
ABSTRACT
Growth factors are a significant advance in the supportive care of patients with cancer with a wide range of indications. Frequent side effects of G-CSF include bone pain, headache, fatigue and nausea. We report a case of subcapsular splenic haematoma following pegfilgrastim administration in a 65-year old patient with multiple myeloma. Proposed mechanisms accounting for splenic enlargement include extramedullary haemopoiesis, intrasplenic infiltration by mature and immature myeloid cells and intrasplenic stem cell homing and proliferation. The risk of spontaneous splenic rupture is difficult to quantify. Physicians should be aware of this life-threatening condition and early diagnosis can be difficult since anemia and splenomegaly are common findings in haematologic patients.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Rotura del Bazo
/
Factor Estimulante de Colonias de Granulocitos
/
Mieloma Múltiple
Tipo de estudio:
Etiology_studies
/
Screening_studies
Límite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Clin Lab Haematol
Año:
2006
Tipo del documento:
Article
País de afiliación:
Grecia