[Immunomodulators of microbial origin enhance cytotoxicity of human mononuclear leukocytes and reduce metastatic progression of Lewis lung carcinoma in mice].
Zh Mikrobiol Epidemiol Immunobiol
; (6): 35-40, 2006.
Article
en Ru
| MEDLINE
| ID: mdl-17163136
ABSTRACT
Effect of immunomodulators for microbial origin on innate immunity and antitumor system was continued to study. Immunomodificator Immunovac VP-4, purified staphylococcal toxoid and glucosaminyl muramyl dipeptide (GMDP) equally enhanced cytotoxicity of mononuclear leukocytes of peripheral blood of healthy donors. Index of cytotoxicity was 2.78, 2.77 and 2.70 respectively. Reduced metastatic progression of Lewis lung carcinoma in mice was observed after Immunovac VP-4 and GMDP administration. Effectiveness was seen when preparations administered according to schedules including their administration before implantation of the tumor. If preparations were administered number of metastases reduced in 4.4-5.6 times and size of metastases reduced in 7-10 times. Interplay between antitumor activity of studied immunomodulators and cytotoxic activity of NK-cells, which are base effectors of antitumor immune response, are discussed.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Leucocitos Mononucleares
/
Vacunas Bacterianas
/
Toxoide Estafilocócico
/
Acetilmuramil-Alanil-Isoglutamina
/
Adyuvantes Inmunológicos
/
Vacunas Combinadas
/
Carcinoma Pulmonar de Lewis
/
Factores Inmunológicos
/
Neoplasias Pulmonares
Límite:
Animals
/
Humans
Idioma:
Ru
Revista:
Zh Mikrobiol Epidemiol Immunobiol
Año:
2006
Tipo del documento:
Article