[Active constituents from Aloe arborescens as BACE inhibitors].
Yao Xue Xue Bao
; 41(10): 1000-3, 2006 Oct.
Article
en Zh
| MEDLINE
| ID: mdl-17184120
ABSTRACT
AIM:
To seek for new components as BACE inhibitors from Aloe arborescens.METHODS:
The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis.RESULTS:
Eight compounds were isolated and their structures identified as 6'-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2'-O-feruloxyl)-beta-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately.CONCLUSION:
Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ácido Aspártico Endopeptidasas
/
Inhibidores Enzimáticos
/
Aloe
/
Secretasas de la Proteína Precursora del Amiloide
Límite:
Humans
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
2006
Tipo del documento:
Article
País de afiliación:
China