Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors.
Bioorg Med Chem Lett
; 17(4): 1127-30, 2007 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-17234415
ABSTRACT
A series of trifluoroacetophenone derivatives were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some of the 'reverse amide' analogs were found to be potent inhibitors of MCD enzyme activity. The trifluoroacetyl group may interact with the MCD active site as the hydrate in a similar fashion to the hexafluoroisopropanol analogs reported previously. Adding electron-withdrawing groups to the phenyl ring stabilizes the hydrated species and enhances this interaction.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Acetofenonas
/
Carboxiliasas
/
Inhibidores Enzimáticos
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos