[Effects of Caulis Sinomenii and sinomenine on morphine-induced place preference and brain histamine level in mice].
Nan Fang Yi Ke Da Xue Xue Bao
; 26(12): 1709-13, 2006 Dec.
Article
en Zh
| MEDLINE
| ID: mdl-17259103
ABSTRACT
OBJECTIVE:
To evaluate the effects of Caulis Sinomenii and sinomenine on conditioned place preference (CPP) induced by morphine and brain histamine level in mice.METHODS:
Sixty mice were randomized into 6 equal groups and morphine (Mor) was injected subcutaneously (9 mg/kg) for 6 consecutive days to induce CPP using a shuttle box. Since the 4th day of training, the mice in 5 of the groups were treated for 3 consecutive days with Caulis Sinomenii (10 g/kg), sinomenine (60 mg/kg), diphenhydramine (30 mg/kg), CP48/80 (5 mg/kg) and L-histidine (750 mg/kg) in addition to morphine (9 mg/kg) treatment, respectively, leaving the other group with exclusive morphine treatment. Another 10 mice received saline injection to serve as saline control group. The content of histamine (HA) in the mouse brain was measured by fluorospectrophotometry.RESULTS:
In morphine group, the mice showed significantly extended stay in morphine-paired compartment whose HA content in the brain was markedly increased (P<0.01). Treatment with Caulis Sinomenii and sinomenine resulted in significantly reduced time of stay in morphine-paired compartment and brain HA level (P<0.01).CONCLUSION:
CPP induced by morphine in mice is associated with increased HA level in the brain. Caulis Sinomenii and sinomenine can suppress the acquisition of place preference induced by morphine and modulate HA level in the central nervous system in morphine-dependent mice.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Histamina
/
Condicionamiento Operante
/
Sinomenium
/
Morfinanos
/
Morfina
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
Zh
Revista:
Nan Fang Yi Ke Da Xue Xue Bao
Año:
2006
Tipo del documento:
Article
País de afiliación:
China