A novel highly stereoselective synthesis of 2,3-disubstituted 3H-quinazoline-4-one derivatives.
Org Lett
; 9(7): 1415-8, 2007 Mar 29.
Article
en En
| MEDLINE
| ID: mdl-17348669
ABSTRACT
[structure see text]. An efficient three-step synthesis of chiral 3H-quinazoline-4-one derivatives from commercial materials is disclosed. The Mumm reaction of imidoyl chloride with alpha-amino acids followed by reductive cyclization affords enantiomerically pure (ee >93%) quinazoline-4-ones in good overall yield. A comparison with existing approaches indicates that this method is superior for hindered substrates.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Quinazolinonas
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos