Reprogramming metastatic tumour cells with embryonic microenvironments.
Nat Rev Cancer
; 7(4): 246-55, 2007 Apr.
Article
en En
| MEDLINE
| ID: mdl-17384580
ABSTRACT
Aggressive tumour cells share many characteristics with embryonic progenitors, contributing to the conundrum of tumour cell plasticity. Recent studies using embryonic models of human stem cells, the zebrafish and the chick have shown the reversion of the metastatic phenotype of aggressive melanoma cells, and revealed the convergence of embryonic and tumorigenic signalling pathways, which may help to identify new targets for therapeutic intervention. This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Embrión de Mamíferos
/
Embrión no Mamífero
/
Melanoma
/
Metástasis de la Neoplasia
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Cancer
Asunto de la revista:
NEOPLASIAS
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos