Microsatellite instability in Bulgarian patients with endometrial cancer.
J BUON
; 12(1): 85-9, 2007.
Article
en En
| MEDLINE
| ID: mdl-17436407
ABSTRACT
PURPOSE:
Microsatellite instability (MSI) is a frequent event in different types of cancer. In several studies MSI was shown to have both clinical and prognostic value. The aim of our study was to determine the frequency of MSI in Bulgarian patients with endometrial cancer (EC) and the possible relation of this phenomenon to their clinicopathological characteristics. PATIENTS ANDMETHODS:
A total of 33 histologically confirmed EC patients were analyzed for tumor MSI using a panel of 6 microsatellite markers.RESULTS:
We identified MSI in 30% of endometrial cancer cases. Six of them had high degree of MSI (MSI-H), and 4 displayed low degree of MSI (MSI-L).CONCLUSION:
The frequency of MSI in Bulgarian EC patients does not differ significantly from that reported in other European studies.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Regulación Neoplásica de la Expresión Génica
/
Neoplasias Endometriales
/
Inestabilidad de Microsatélites
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
J BUON
Asunto de la revista:
NEOPLASIAS
Año:
2007
Tipo del documento:
Article
País de afiliación:
Bulgaria