Tissue uptake of thyroid hormone by amino acid transporters.
Best Pract Res Clin Endocrinol Metab
; 21(2): 237-51, 2007 Jun.
Article
en En
| MEDLINE
| ID: mdl-17574006
ABSTRACT
Thyroid hormones (THs) -- thyroxine (T4) and tri-iodothyronine (T3) -- are iodinated derivatives of the amino acid tyrosine, which regulates growth, development and critical metabolic functions. THs are taken up by target cells and act at the genomic level via nuclear thyroid receptors. Saturable transport mechanisms mediate the greater part of TH movement across the plasma membrane. System L1 permease is a transporter of THs and amino acids in mammalian adipose tissue, placenta and brain. T(3) is also a substrate of a putative System T transporter, which is selective for aromatic amino acids. The activity and functional mechanisms of these transporters can be crucial to cells in determining both their hormone sensitivity and their responses to change in circulating hormone concentrations or availability of competing substrates (e.g. amino acids). TH transporters are potentially important pharmacological targets in the design of novel or improved therapies for thyroid-related disorders.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hormonas Tiroideas
/
Sistemas de Transporte de Aminoácidos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Best Pract Res Clin Endocrinol Metab
Asunto de la revista:
ENDOCRINOLOGIA
/
METABOLISMO
Año:
2007
Tipo del documento:
Article
País de afiliación:
Reino Unido