SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer.

Wickens, Philip; Kluender, Harold; Dixon, Julie; Brennan, Catherine; Achebe, Furahi; Bacchiocchi, Antonella; Bankston, Don; Bierer, Donald; Brands, Michael; Braun, Debbie; Brown, Melissa S; Chuang, Chih-Yuan; Dumas, Jacques; Enyedy, Istvan; Hofilena, Gloria; Hong, Zhenqiu; Housley, Tim; Jones, Benjamin; Khire, Uday; Kreiman, Charles; Kumarasinghe, Ellalahewage; Lowinger, Timothy; Ott-Morgan, Ronda; Perkins, Louise; Phillips, Barton; Schoenleber, Robert; Scott, William J; Sheeler, Ryan; Redman, Anikó; Sun, Xiuying; Taylor, Ian; Wang, Lei; Wilhelm, Scott; Zhang, Xiaomei; Zhang, Mingbao; Sullivan, Elizabeth; Carter, Christopher; Miglarese, Mark; Levy, Joan

Wickens, Philip; Kluender, Harold; Dixon, Julie; Brennan, Catherine; Achebe, Furahi; Bacchiocchi, Antonella; Bankston, Don; Bierer, Donald; Brands, Michael; Braun, Debbie; Brown, Melissa S; Chuang, Chih-Yuan; Dumas, Jacques; Enyedy, Istvan; Hofilena, Gloria; Hong, Zhenqiu; Housley, Tim; Jones, Benjamin; Khire, Uday; Kreiman, Charles; Kumarasinghe, Ellalahewage; Lowinger, Timothy; Ott-Morgan, Ronda; Perkins, Louise; Phillips, Barton; Schoenleber, Robert; Scott, William J; Sheeler, Ryan; Redman, Anikó; Sun, Xiuying; Taylor, Ian; Wang, Lei; Wilhelm, Scott; Zhang, Xiaomei; Zhang, Mingbao; Sullivan, Elizabeth; Carter, Christopher; Miglarese, Mark; Levy, Joan.

Afiliación

Wickens P; Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. pcwickens@hotmail.com

Bioorg Med Chem Lett ; 17(15): 4378-81, 2007 Aug 01.

Article en En | MEDLINE | ID: mdl-17574417

RESUMEN

Novel anthranilamides were surprisingly found to exert additional activity on B-RAF. Corresponding thiophene, pyrazole, and thiazole core analogs were prepared as VEGFR-2 inhibitors with c-KIT, and B-RAF activity. Compounds in the phenyl, thiophene, and thiazole series are in vivo active.

Asunto(s)

Antineoplásicos/farmacología; Neoplasias/tratamiento farmacológico; Inhibidores de Proteínas Quinasas/farmacología; Receptor 2 de Factores de Crecimiento Endotelial Vascular/antagonistas & inhibidores; Animales; Antineoplásicos/uso terapéutico; Línea Celular Tumoral; Humanos; Ratones; Inhibidores de Proteínas Quinasas/uso terapéutico; Relación Estructura-Actividad

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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptor 2 de Factores de Crecimiento Endotelial Vascular / Inhibidores de Proteínas Quinasas / Neoplasias / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2007 Tipo del documento: Article País de afiliación: Estados Unidos

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