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A collective form of cell death requires homeodomain interacting protein kinase.
Link, Nichole; Chen, Po; Lu, Wan-Jin; Pogue, Kristi; Chuong, Amy; Mata, Miguel; Checketts, Joshua; Abrams, John M.
Afiliación
  • Link N; Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
J Cell Biol ; 178(4): 567-74, 2007 Aug 13.
Article en En | MEDLINE | ID: mdl-17682052
ABSTRACT
We examined post-eclosion elimination of the Drosophila wing epithelium in vivo where collective "suicide waves" promote sudden, coordinated death of epithelial sheets without a final engulfment step. Like apoptosis in earlier developmental stages, this unique communal form of cell death is controlled through the apoptosome proteins, Dronc and Dark, together with the IAP antagonists, Reaper, Grim, and Hid. Genetic lesions in these pathways caused intervein epithelial cells to persist, prompting a characteristic late-onset blemishing phenotype throughout the wing blade. We leveraged this phenotype in mosaic animals to discover relevant genes and establish here that homeodomain interacting protein kinase (HIPK) is required for collective death of the wing epithelium. Extra cells also persisted in other tissues, establishing a more generalized requirement for HIPK in the regulation of cell death and cell numbers.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Muerte Celular / Drosophila Límite: Animals Idioma: En Revista: J Cell Biol Año: 2007 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Muerte Celular / Drosophila Límite: Animals Idioma: En Revista: J Cell Biol Año: 2007 Tipo del documento: Article País de afiliación: Estados Unidos