mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity.
Mol Psychiatry
; 13(10): 970-9, 2008 Oct.
Article
en En
| MEDLINE
| ID: mdl-17712315
Formation and extinction of aversive memories in the mammalian brain are insufficiently understood at the cellular and molecular levels. Using the novel metabotropic glutamate receptor 7 (mGluR7) agonist AMN082, we demonstrate that mGluR7 activation facilitates the extinction of aversive memories in two different amygdala-dependent tasks. Conversely, mGluR7 knockdown using short interfering RNA attenuated the extinction of learned aversion. mGluR7 activation also blocked the acquisition of Pavlovian fear learning and its electrophysiological correlate long-term potentiation in the amygdala. The finding that mGluR7 critically regulates extinction, in addition to acquisition of aversive memories, demonstrates that this receptor may be relevant for the manifestation and treatment of anxiety disorders.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Reacción de Prevención
/
Receptores de Glutamato Metabotrópico
/
Extinción Psicológica
/
Amígdala del Cerebelo
/
Memoria
/
Plasticidad Neuronal
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Mol Psychiatry
Asunto de la revista:
BIOLOGIA MOLECULAR
/
PSIQUIATRIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Suiza