(1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production.
Bioorg Med Chem Lett
; 17(21): 5983-8, 2007 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-17827000
ABSTRACT
Synthesis, pharmacology, and pharmacokinetic profiles of (1R, 2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile are reported. This compound demonstrated remarkable potency for stimulating hair growth in a male C3H mouse model as well as reducing sebum production in the male Syrian hamster ear model.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sebo
/
Cabello
/
Hidrocarburos Fluorados
/
Antagonistas de Andrógenos
/
Nitrilos
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos