Effects of cicletanine on vasoactive systems in conscious sinoaortic-denervated dogs.
Fundam Clin Pharmacol
; 5(8): 719-32, 1991.
Article
en En
| MEDLINE
| ID: mdl-1783361
ABSTRACT
The present study investigates the antihypertensive action of cicletanine, a new antihypertensive compound with diuretic properties (or placebo), on vasopressor (catecholamines, renin-aldosterone) as well as vasodepressor (prostaglandins, kallikrein-kinin) systems in conscious chronic sinoaortic denervated (SAD) dogs. Cicletanine (10 mg/kg twice a day, per os, for one month) lowered blood pressure and heart rate. The antihypertensive action does not involve an effect on sympathetic tone (since plasma catecholamine levels were unmodified) or on plasma aldosterone levels. By contrast, urinary 6 keto PGF1 or PGE2 levels and kallikrein activity were enhanced. This result indicates that the antihypertensive effect of cicletanine is associated with a stimulation of potential vasodepressor systems (such as prostaglandins or kinins).
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piridinas
/
Presión Sanguínea
/
Diuréticos
/
Frecuencia Cardíaca
/
Hipertensión
/
Antihipertensivos
Límite:
Animals
Idioma:
En
Revista:
Fundam Clin Pharmacol
Asunto de la revista:
FARMACOLOGIA
Año:
1991
Tipo del documento:
Article
País de afiliación:
Francia