Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans.
Genetics
; 177(1): 655-60, 2007 Sep.
Article
en En
| MEDLINE
| ID: mdl-17890369
ABSTRACT
Here we show that in the nematode Caenorhabditis elegans mutational inactivation of two autophagy genes unc-51/atg1 and bec-1/atg6/beclin1 results in small body size without affecting cell number. Furthermore, loss-of-function mutations in unc-51 and bec-1 suppress the giant phenotype of mutant animals with aberrant insulin-like growth factor-1 (insulin/IGF-1) or transforming growth factor-beta (TGF-beta) signaling. This function for unc-51 and bec-1 in cell size control and their interaction with these two growth modulatory pathways may represent a link between the hormonal and nutritional regulation of cell growth.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Autofagia
/
Proteínas Serina-Treonina Quinasas
/
Caenorhabditis elegans
/
Proteínas de Caenorhabditis elegans
/
Tamaño de la Célula
Límite:
Animals
Idioma:
En
Revista:
Genetics
Año:
2007
Tipo del documento:
Article
País de afiliación:
Hungria