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Prediction of premature atherosclerosis by endothelial dysfunction and increased intima-media thickness in glycogen storage disease types Ia and III.
Yekeler, Ensar; Dursun, Memduh; Emeksiz, Eda; Akkoyunlu, Murat; Akyol, Yakup; Demir, Fikri; Gökcay, Gülden; Demirkol, Mübeccel.
Afiliación
  • Yekeler E; Department of Radiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
Turk J Pediatr ; 49(2): 115-9, 2007.
Article en En | MEDLINE | ID: mdl-17907509
The aim of this study was to investigate the endothelial dysfunction (ED) and carotid intima-media thickness (IMT) in patients with glycogen storage disease (GSD) types Ia and III. In 22 patients with GSD (13, type Ia; 9, type III) and 18 healthy subjects, endothelial functions of the brachial artery and carotid IMT were evaluated by high-resolution ultrasound. Endothelial-dependent dilatation (EDD) was assessed by establishing reactive hyperemia. EDD and carotid IMTs were compared between the three groups. Mean cholesterol level was slightly higher in GSD type III patients but the difference was not significant. Triglyceride levels and cholesterol to high density lipoprotein (HDL) ratio were significantly higher in GSD type Ia patients. EDD was significantly impaired in GSD type Ia (13% +/- 8%, P = .001) and type III (15% +/- 6%, P = .005) patients when compared with the healthy subjects (22% +/- 4%). The carotid IMT was significantly higher in both GSD type Ia (0.23 +/- 0.03 mm, P =.005) and type III (0.26 +/- 0.05 mm, P = .001) patients when compared with the healthy subjects (0.20 +/- 0.02 mm). Both GSD type Ia and type III patients show significant ED and increased IMT, which are predictors of atherosclerosis.
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Endotelio Vascular / Enfermedad del Almacenamiento de Glucógeno Tipo I / Enfermedad del Almacenamiento de Glucógeno Tipo III / Túnica Media / Aterosclerosis Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Turk J Pediatr Año: 2007 Tipo del documento: Article País de afiliación: Turquía
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Endotelio Vascular / Enfermedad del Almacenamiento de Glucógeno Tipo I / Enfermedad del Almacenamiento de Glucógeno Tipo III / Túnica Media / Aterosclerosis Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Turk J Pediatr Año: 2007 Tipo del documento: Article País de afiliación: Turquía