The T/G 13915 variant upstream of the lactase gene (LCT) is the founder allele of lactase persistence in an urban Saudi population.
J Med Genet
; 44(10): e89, 2007 Oct.
Article
en En
| MEDLINE
| ID: mdl-17911653
ABSTRACT
BACKGROUND:
The prevalence of lactase persistence is high in Saudi Arabia.OBJECTIVE:
To identify a DNA variant for the lactase persistence/non-persistence trait in adult Arabs in Saudi Arabia.METHODS:
We sequenced DNA from 432 anonymous neonatal blood donors from five different regions of Saudi Arabia to cover the 400 bp region surrounding the previously identified lactase persistence/non-persistence variant C/T-13910 residing in intron 13 of the MCM6 gene.RESULTS:
Two anonymous blood donors carried the C/T-13910 genotype. One variant, T/G -13915, residing 5 bp upstream of the C/T-13910 variant, was present in 332 of 432 (76.9%) of the neonatal samples, compatible with previous prevalence figures of lactase persistence in urban Saudi populations. Determination of disaccharidase activities in 25 intestinal biopsy samples showed a highly significant correlation between lactase activity and the T/G-13915 genotypes (p<0.001; Fisher exact test) as well as between the LS ratio and the aforementioned genotypes (p<0.001; Fisher exact test).CONCLUSION:
The T/G-13915 variant is the founder mutation of lactase persistence in an urban Saudi population. The results obtained here have implications for genetic testing of adult-type hypolactasia and to analysis of human evolution, the origin of cattle domestication and migrations of the populations in the Arabian peninsula.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Variación Genética
/
Regulación de la Expresión Génica
/
Lactasa
/
Lactatos
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
/
Newborn
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Med Genet
Año:
2007
Tipo del documento:
Article
País de afiliación:
Arabia Saudita