Synthesis of phosphorothioate oligonucleotide-peptide conjugates by solid phase fragment condensation.
Bioorg Med Chem Lett
; 17(23): 6576-8, 2007 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-17942304
ABSTRACT
Phosphorothioate oligonucleotide-peptide conjugates were synthesized by solid phase fragment condensation (SPFC). Arginine rich peptides could be successfully conjugated in 2.8-13.4% isolated yields. All the products were fully characterized by reversed phase HPLC and MALDI-TOF-MS to give satisfactory results.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Oligonucleótidos Fosforotioatos
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Japón