[Genetic polymorphism of COMT in mental disorders]. / Polimorfizm genu COMT w zaburzeniach psychicznych.
Psychiatr Pol
; 41(4): 473-83, 2007.
Article
en Pl
| MEDLINE
| ID: mdl-18046978
ABSTRACT
Many neurobiochemical studies show abnormalities within dopaminergic neuropathways, particularly altered dopamine transmission in etiopathogenesis of mental disorders. Evaluation of genes associated with the dopaminergic system include five well known subtypes of dopaminergic receptors, dopamine transporter and enzymes associated with the synthesis and degradation of dopamine, such as tyrosine hydroxylase, dopa decarboxylase, monoamine oxidase (MAO) and catechol O-methyltransferase (COMT). None of these genes is 'a' pathognomonic factor of schizophrenia onset. In each sequence of the following genes 'a' functional polymorphism can occur. The polymorphisms of genes MAO-A and COMT have been described in relation to various expression or altered activity of these enzymes, their influence on cognitive functions, affective and anxiety disorders, learning disabilities, aggressive behaviour, eating disorders or gender differences.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Catecol O-Metiltransferasa
/
Predisposición Genética a la Enfermedad
/
Trastornos Mentales
/
Monoaminooxidasa
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
Pl
Revista:
Psychiatr Pol
Año:
2007
Tipo del documento:
Article