Genetically engineered rat models for breast cancer.

Smits, Bart M G; Cotroneo, Michelle S; Haag, Jill D; Gould, Michael N

Smits, Bart M G; Cotroneo, Michelle S; Haag, Jill D; Gould, Michael N.

Afiliación

Smits BM; McArdle Lab for Cancer Research, University of Wisconsin - Madison, Madison, WI 53706, USA.

Breast Dis ; 28: 53-61, 2007.

Article en En | MEDLINE | ID: mdl-18057543

RESUMEN

Rat mammary cancers generally resemble many features of human breast cancer. With the recent developments in rat genetic engineering, the rat has become an excellent model system to study aspects of the molecular etiology of breast cancer. In this review, we describe the efforts to generate genetically engineered rat models for breast cancer.

Asunto(s)

Neoplasias de la Mama/genética; Neoplasias Mamarias Experimentales/genética; Animales; Animales Modificados Genéticamente; Neoplasias de la Mama/metabolismo; Femenino; Genes BRCA1; Genes BRCA2; Genes ras; Humanos; Neoplasias Mamarias Experimentales/metabolismo; Ratas; Receptor ErbB-2/metabolismo; Transfección

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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Neoplasias Mamarias Experimentales Límite: Animals / Female / Humans Idioma: En Revista: Breast Dis Asunto de la revista: GINECOLOGIA Año: 2007 Tipo del documento: Article País de afiliación: Estados Unidos

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