In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series.

Nersesian, Diana L; Black, Lawrence A; Miller, Thomas R; Vortherms, Timothy A; Esbenshade, Timothy A; Hancock, Arthur A; Cowart, Marlon D

Nersesian, Diana L; Black, Lawrence A; Miller, Thomas R; Vortherms, Timothy A; Esbenshade, Timothy A; Hancock, Arthur A; Cowart, Marlon D.

Afiliación

Nersesian DL; Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. diana.nersesian@abbott.com

Bioorg Med Chem Lett ; 18(1): 355-9, 2008 Jan 01.

Article en En | MEDLINE | ID: mdl-18077160

ABSTRACT

ABSTRACT

Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine.

Asunto(s)

Antagonistas de los Receptores Histamínicos H3/química; Antagonistas de los Receptores Histamínicos H3/farmacología; Pirrolidinas/química; Pirrolidinas/farmacología; Animales; Humanos; Cinética; Ratas; Relación Estructura-Actividad

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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirrolidinas / Antagonistas de los Receptores Histamínicos H3 Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2008 Tipo del documento: Article País de afiliación: Estados Unidos

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