A general route to pendant C-glycosyl 1,2- and 1,3-diamines.
Carbohydr Res
; 343(5): 941-50, 2008 Apr 07.
Article
en En
| MEDLINE
| ID: mdl-18281023
ABSTRACT
Practical and convenient preparations of C-glycosyl 1,2- and 1,3-alkanediamines are described. Two 1,2-ethylenediamine derivatives were synthesized from acetylated allyl alpha-C-glycosyl compounds via dibromination, azidation, carbohydrate deprotection, and azide reduction. Four 1,3-propanediamine derivatives were prepared from acetylated sugar halides via C-glycosylation with sodiomalononitrile, followed by the reduction of the nitrile moieties and the deacetylation of the carbohydrate moiety. These 1,3-propanediamine derivatives have the beta-anomeric configurations. The methods reported here serve as general routes to access carbohydrate-diamine conjugates with C-glycosyl linkages.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Diaminas
/
Glicósidos
Idioma:
En
Revista:
Carbohydr Res
Año:
2008
Tipo del documento:
Article
País de afiliación:
Japón