Occlusal stimuli influence on the expression of IGF-1 and the IGF-1 receptor in the rat periodontal ligament.
Angle Orthod
; 78(4): 610-6, 2008 Jul.
Article
en En
| MEDLINE
| ID: mdl-18302458
ABSTRACT
OBJECTIVE:
To test the hypothesis that hypofunction/recovered occlusal function has no effect on the changes in insulin-like growth factor-1 (IGF-1) and IGF-1 receptor expressions and cell proliferation of periodontal ligament (PDL) cells. MATERIALS ANDMETHODS:
To produce occlusal hypofunction, the appliances were attached to the rats' maxillary and mandibular incisors. Subsequently, occlusal contact of the molar area was thoroughly recovered by removal of the appliances.RESULTS:
In periodontal sections, localization of IGF-1, the IGF-1 receptor, and proliferating cell nuclear antigen (PCNA) immunoreactive cells was significantly more expressed in the control group compared with the hypofunctional group (P < .01). In addition, after the recovery of the occlusion, IGF-1, IGF-1 receptor, and PCNA were detected significantly much more than in the hypofunction group (P < .01).CONCLUSION:
The hypothesis was rejected. This study suggests that occlusal stimuli induce cell proliferation of PDL cells by increasing IGF-1 and IGF-1 receptor expression.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ligamento Periodontal
/
Fuerza de la Mordida
/
Factor I del Crecimiento Similar a la Insulina
/
Receptor IGF Tipo 1
/
Análisis del Estrés Dental
Límite:
Animals
Idioma:
En
Revista:
Angle Orthod
Año:
2008
Tipo del documento:
Article
País de afiliación:
Japón