beta-N-acetylhexosaminidases in human cerebrospinal fluid and serum of patients with multiple sclerosis.
Clin Chim Acta
; 200(2-3): 73-80, 1991 Aug 30.
Article
en En
| MEDLINE
| ID: mdl-1838034
ABSTRACT
Beta-N-Acetylhexosaminidase activity and isoenzyme have been investigated in normal human cerebrospinal fluid and that of patients with multiple sclerosis. beta-N-acetylhexosaminidase activity in normal cerebrospinal fluids has been resolved into five components. The major component was in a form that eluted from DEAE cellulose at the same salt concentration as hexosaminidase As, the isoenzyme previously identified in human serum. Cerebrospinal fluid from patients exhibited a different isoenzyme profile, showing a remarkable increase in a form having a pI which was more acidic than that of As. These changes have a potential use in the diagnosis and further biochemical characterization of multiple sclerosis.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Beta-N-Acetilhexosaminidasas
/
Isoenzimas
/
Esclerosis Múltiple
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Límite:
Humans
Idioma:
En
Revista:
Clin Chim Acta
Año:
1991
Tipo del documento:
Article
País de afiliación:
Italia