InteroPORC: automated inference of highly conserved protein interaction networks.
Bioinformatics
; 24(14): 1625-31, 2008 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-18508856
ABSTRACT
MOTIVATION Protein-protein interaction networks provide insights into the relationships between the proteins of an organism thereby contributing to a better understanding of cellular processes. Nevertheless, large-scale interaction networks are available for only a few model organisms. Thus, interologs are useful for a systematic transfer of protein interaction networks between organisms. However, no standard tool is available so far for that purpose. RESULTS:
In this study, we present an automated prediction tool developed for all sequenced genomes available in Integr8. We also have developed a second method to predict protein-protein interactions in the widely used cyanobacterium Synechocystis. Using these methods, we have constructed a new network of 8783 inferred interactions for Synechocystis.AVAILABILITY:
InteroPORC is open-source, downloadable and usable through a web interface at http//biodev.extra.cea.fr/interoporc/.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas
/
Cianobacterias
/
Biología Computacional
/
Mapeo de Interacción de Proteínas
/
Synechocystis
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Bioinformatics
Asunto de la revista:
INFORMATICA MEDICA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Francia