Calcium supplementation during pregnancy for preventing hypertensive disorders is not associated with changes in platelet count, urate, and urinary protein: a randomized control trial.
Hypertens Pregnancy
; 27(3): 299-304, 2008.
Article
en En
| MEDLINE
| ID: mdl-18696358
ABSTRACT
OBJECTIVE:
To test the hypothesis that calcium supplementation inhibits the underlying pathological processes in women with preeclampsia.METHODS:
Seven hundred and eight nulliparous women were enrolled in a WHO randomized double-blind trial, who received 1.5 g of calcium or placebo from 20 weeks of pregnancy or earlier. Platelet count, serum urate, and urinary protein/creatinine ratio were measured at or near 35 gestational weeks.RESULTS:
No difference was detected in rates of abnormal platelet count (relative risk [RR] 1.18; 95% confidence interval [CI], 0.63 to 2.18), serum urate level (1.0; 0.64 to 1.57) or urine protein/creatinine ratio (1.01; 0.76 to 1.34). This was consistent with the main trial finding of no difference in the incidence of 'dipstick' proteinuria between women receiving calcium and those receiving placebo (8312 women; RR, 1.01; 95% CI, 0.88 to 1.15).CONCLUSIONS:
An effect of calcium supplementation in the second half of pregnancy on the rate of abnormal laboratory measures associated with preeclampsia was not demonstrated.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Preeclampsia
/
Proteinuria
/
Ácido Úrico
/
Calcio
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Hypertens Pregnancy
Asunto de la revista:
ANGIOLOGIA
/
OBSTETRICIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Sudáfrica