ORMDL3--guilt by association?
Clin Exp Allergy
; 38(10): 1579-81, 2008 Oct.
Article
en En
| MEDLINE
| ID: mdl-18754760
ABSTRACT
A recent British-German study described ORMDL3 as a new asthma gene. Although the association with chromosome 17q12 marker is plausible from earlier linkage data, it is far from being clear which gene caused the association signal, as it is derived from a large linkage disequilibrium (LD) block. Not only Aiolos and GSDML but also distant genes that are regulated by this site may be relevant. There may be even unidentified RNA transcripts requiring a much more detailed genetic and functional analysis before finding ORMDL3 guilty by association.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Asma
/
Cromosomas Humanos Par 17
/
Proteínas de la Membrana
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Clin Exp Allergy
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Alemania