Discovery of thieno[2,3-c]pyridines as potent COT inhibitors.
Bioorg Med Chem Lett
; 18(18): 4952-5, 2008 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-18755587
ABSTRACT
Evaluation of hit chemotypes from high throughput screening identified a novel series of 2,4-disubstituted thieno[2,3-c]pyridines as COT kinase inhibitors. Structural modifications exploring SAR at the 2- and 4-positions resulting in inhibitors with improved enzyme potency and cellular activity are disclosed.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piridinas
/
Tiofenos
/
Modelos Moleculares
/
Proteínas Proto-Oncogénicas
/
Quinasas Quinasa Quinasa PAM
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos