Drug resistance mutation profile and accumulation kinetics in human immunodeficiency virus-positive individuals infected with subtypes B and F failing highly active antiretroviral therapy are influenced by different viral codon usage patterns.
Antimicrob Agents Chemother
; 52(12): 4497-502, 2008 Dec.
Article
en En
| MEDLINE
| ID: mdl-18838582
ABSTRACT
The major human immunodeficiency virus type 1 subtype circulating in Brazil is B, followed by F and C. We have genotyped 882 samples from Brazilian patients for whom highly active antiretroviral therapy failed, and we found subtype B and the unique recombinant B/F1 forms circulating. Due to codon usage variation, there is a significantly lower incidence of the substitutions L210W, Q151M, and F116Y in subtype F1 isolates than in the subtype B counterparts.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Codón
/
Infecciones por VIH
/
VIH-1
/
Terapia Antirretroviral Altamente Activa
/
Farmacorresistencia Viral
/
Mutación
Límite:
Female
/
Humans
/
Male
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2008
Tipo del documento:
Article
País de afiliación:
Brasil