Effects of lanthanum on human lymphocytes viability and DNA strand break.
Bull Environ Contam Toxicol
; 82(4): 423-7, 2009 Apr.
Article
en En
| MEDLINE
| ID: mdl-18979059
ABSTRACT
Lanthanum (La) is a rare-earth metal with applications in agriculture, industry, and medicine. Since lanthanides show a broad spectrum of applications there is an increased risk of contamination for humans. We examined the effects of lanthanum in Jurkat cells and human peripheral lymphocytes (HPL), and we found that it was cytotoxic and genotoxic on both cell lines. Additionally, HPL were more sensitive to La treatment than Jurkat cells and necrosis was the pathway by which La induced cytotoxicity. Vitamin E was able to diminish the DNA strand breaks induced suggesting that oxidative stress may be involved in the genotoxic process.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Carcinógenos
/
Linfocitos
/
Contaminantes Ambientales
/
Lantano
/
Mutágenos
Límite:
Humans
Idioma:
En
Revista:
Bull Environ Contam Toxicol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Brasil