Accumulation of advanced glycation end products and chronic complications in ESRD treated by dialysis.
Am J Kidney Dis
; 53(1): 138-50, 2009 Jan.
Article
en En
| MEDLINE
| ID: mdl-19036487
ABSTRACT
Cardiovascular and connective tissue disorders are very common in patients with end-stage renal disease (ESRD), and the accumulation of advanced glycation end products (AGEs) is significantly increased in these patients. Accumulation of AGEs is believed to have a role in tissue protein aging and the pathogenesis of such age-related diseases as diabetes and ESRD. AGEs accumulate in patients with ESRD as a result of nonenzymatic glycation, oxidative stress, and diminished clearance of AGE precursors. Some AGEs show characteristic brown pigmentation and fluorescence, form protein-protein cross-links, and may ligate with AGE-specific receptors, inducing oxidative stress and cytokine production. This review focuses on the clinical relevance of AGE accumulation in patients with ESRD treated by dialysis for the development of long-term complications. The formation and accumulation of AGEs in patients with ESRD are discussed, as well as the relationship between AGE accumulation and such major complications of ESRD as cardiovascular and connective tissue disorders.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Diálisis Renal
/
Productos Finales de Glicación Avanzada
/
Fallo Renal Crónico
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Am J Kidney Dis
Año:
2009
Tipo del documento:
Article
País de afiliación:
Países Bajos