Reduced incidence of Marek's disease gross lymphomas in T-cell-depleted chickens.
J Natl Cancer Inst
; 58(3): 689-92, 1977 Mar.
Article
en En
| MEDLINE
| ID: mdl-190413
ABSTRACT
Chickens of line 7, highly susceptible to Marek's disease (MD), were depleted of T-cells by neonatal thymectomy, total-body gamma-irradiation, and multiple injections with antithymocyte serum. In two replicate experiments, significantly fewer gross lymphomas were present in T-cell-depleted chickens than in intact or in T-cell-depleted, reconstituted hatchmates; these findings provided evidence that T-cells may be the principal target for MD virus (MDV) transformation, T-cell depletion was not complete, and the presence of microscopic lesions in T-cell-depleted chickens was attributed to residual T-cells. Ten lymphomas from intact chickens and 2 lymphomas from a T-cell-depleted chicken were examined for cellular composition. All lymphomas consisted predominantly of T-cells. The results of this and other published studies indicated that T-cells may have a dual role in MD; They may serve as a target for lymphoma formation by MDV and also may participate in immune surveillance against the disease in resistant chickens.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Enfermedad de Marek
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
J Natl Cancer Inst
Año:
1977
Tipo del documento:
Article