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Excitatory and inhibitory purinergic control of neck muscle nociception in anaesthetized mice.
Reitz, M; Makowska, A; Ellrich, J.
Afiliación
  • Reitz M; Experimental Neurosurgery Section, Department of Neurosurgery, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Cephalalgia ; 29(1): 58-67, 2009 Jan.
Article en En | MEDLINE | ID: mdl-19126119
Tension-type headache is associated with noxious input from neck muscles. Due to the importance of purinergic mechanisms in muscle nociception, experimental studies typically inject alpha,beta-methyleneadenosine 5'-triphosphate (alpha,beta-meATP). In contrast to native adenosine 5'-triphosphate (ATP), alpha,beta-meATP has a narrow receptor profile and remains stable in tissue. The present study administered alpha,beta-meATP or ATP in semi-spinal neck muscles in anaesthetized mice (n = 65) in order to address different effects in neck muscle nociception. The jaw-opening reflex monitored the impact of neck muscle noxious input on brainstem processing. Injection of alpha,beta-meATP induced reflex facilitation in a dose-dependent manner. In contrast, only the lowest ATP dosage evoked facilitation. Preceding P2Y(1) receptor blockade revealed facilitation even under high-dosage ATP. Ongoing facilitation after alpha,beta-meATP injection neutralized under subsequent activation of P2Y(1) receptors. Results demonstrate opposing excitatory P2X and inhibitory P2Y effects of ATP in neck muscle nociception. These mechanisms may be involved in the pathophysiology of neck muscle pain in man.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Dolor / Vías Aferentes / Receptores Purinérgicos P2 / Cefalea de Tipo Tensional / Músculos del Cuello Límite: Animals Idioma: En Revista: Cephalalgia Año: 2009 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Dolor / Vías Aferentes / Receptores Purinérgicos P2 / Cefalea de Tipo Tensional / Músculos del Cuello Límite: Animals Idioma: En Revista: Cephalalgia Año: 2009 Tipo del documento: Article País de afiliación: Alemania