Antibiofilm activity of a diverse oroidin library generated through reductive acylation.
J Org Chem
; 74(4): 1755-8, 2009 Feb 20.
Article
en En
| MEDLINE
| ID: mdl-19132935
ABSTRACT
A diverse 20-compound library of analogues based on the marine alkaloid oroidin were synthesized via a reductive acylation strategy. The final target was then assayed for inhibition and dispersion activity against common proteobacteria known to form biofilms. This methodology represents a significant improvement over the generality of known methods to acylate substrates containing 2-aminoimidazoles and has the potential to have broad application to the synthesis of more advanced oroidin family members and their corresponding analogues.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pirroles
/
Biopelículas
/
Bibliotecas de Moléculas Pequeñas
Idioma:
En
Revista:
J Org Chem
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos