Ciliar functions in the nephron.
Pflugers Arch
; 458(1): 179-87, 2009 May.
Article
en En
| MEDLINE
| ID: mdl-19153764
ABSTRACT
The primary cilium is a microtubule-based nonmotile organelle that is found on most cells in the mammalian body. Once regarded as a vestigial organelle, it has been recently shown to play unforeseen roles in mammalian physiology and tissue homeostasis. In kidney epithelial cells, the primary cilium plays a fundamental role in tubule organization and function and it is now considered to serve as a versatile mechanosensor and chemosensor. Diseases related to kidney primary cilia include autosomal polycystic kidney disease, recessive polycystic kidney disease, Bardet-Biedl syndrome, and nephronophthisis. Multiple proteins whose functions are disrupted in cystic kidney diseases have been localized in the primary cilium. This review provides a general introduction to the cell biology and function of renal primary cilia and an overview of cilia-related kidney diseases.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cilios
/
Nefronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Pflugers Arch
Año:
2009
Tipo del documento:
Article
País de afiliación:
Francia