Independent clonal origin of T- and B-cell clones in a composite lymphoma.
Leuk Res
; 15(9): 811-7, 1991.
Article
en En
| MEDLINE
| ID: mdl-1921459
ABSTRACT
We present a detailed immunohistological and genotypic analysis of an unusual case in which a peripheral T-cell lymphoma, with features of Lennert's and angioimmunoblastic lymphoma, occurred after treatment of a low grade plasmacytoid lymphoma. By analysis of immunoglobulin and T-cell receptor genes, we show that the two diseases had an independent clonal origin at the level of lymphoid commitment. However, by employing a novel polymerase chain reaction-based technique for analysis of B-cell clonality, we show the persistence of a residual minor clonal B-cell population in the subsequent T-cell lymphoma. Only 2 previous cases of composite lymphoma involving B- and T-cell clones have been demonstrated by molecular analysis. This study underlines the immunophenotypic and genotypic heterogeneity of peripheral T-cell lymphomas and illustrates an unusual disease course in which a T-cell lymphoma has arisen in the context of, and perhaps as a consequence of, a B-cell lymphoma.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Linfocitos T
/
Leucemia Linfocítica Crónica de Células B
/
Linfoma de Células T Periférico
/
Neoplasias Primarias Secundarias
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Leuk Res
Año:
1991
Tipo del documento:
Article
País de afiliación:
Reino Unido