World Health Organisation multicentre randomised trial of supplementation with vitamins C and E among pregnant women at high risk for pre-eclampsia in populations of low nutritional status from developing countries.
BJOG
; 116(6): 780-8, 2009 May.
Article
en En
| MEDLINE
| ID: mdl-19432566
ABSTRACT
OBJECTIVE:
To determine if vitamin C and E supplementation in high-risk pregnant women with low nutritional status reduces pre-eclampsia.DESIGN:
Multicentred, randomised, controlled, double-blinded trial.SETTING:
Antenatal care clinics and Hospitals in four countries. POPULATION Pregnant women between 14 and 22 weeks' gestation.METHOD:
Randomised women received 1000 mg vitamin C and 400 iu of vitamin E or placebo daily until delivery. MAIN OUTCOMEMEASURES:
Pre-eclampsia, low birthweight, small for gestational age and perinatal death.RESULTS:
Six hundred and eighty-seven women were randomised to the vitamin group and 678 to the placebo group. Groups had similar gestational ages (18.1; SD 2.4 weeks), socio-economic, clinical and demographical characteristics and blood pressure at trial entry. Risk factors for eligibility were similar, except for multiple pregnancies placebo group (14.7%), vitamins group (11.8%). Previous pre-eclampsia, or its complications, was the most common risk factor at entry (vitamins 41.6%, placebo 41.3%). Treatment compliance was 87% in the two groups and loss to follow-up was low (vitamins 2.0%, placebo 1.3%). Supplementation was not associated with a reduction of pre-eclampsia (RR 1.0; 95% CI 0.9-1.3), eclampsia (RR 1.5; 95% CI 0.3-8.9), gestational hypertension (RR 1.2; 95% CI 0.9-1.7), nor any other maternal outcome. Low birthweight (RR 0.9; 95% CI 0.8-1.1), small for gestational age (RR 0.9; 95% CI 0.8-1.1) and perinatal deaths (RR 0.8; 95% CI 0.6-1.2) were also unaffected.CONCLUSION:
Vitamins C and E at the doses used did not prevent pre-eclampsia in these high-risk women.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Preeclampsia
/
Ácido Ascórbico
/
Vitamina E
/
Suplementos Dietéticos
/
Países en Desarrollo
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
BJOG
Asunto de la revista:
GINECOLOGIA
/
OBSTETRICIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Reino Unido