[Advances in helper-dependent adenoviral vector--a review review].
Wei Sheng Wu Xue Bao
; 49(2): 147-52, 2009 Feb.
Article
en Zh
| MEDLINE
| ID: mdl-19445167
Helper-dependent adenoviral vector (HDAd) lacking all viral coding sequences with the advantages of minimal immunogenicity, negligible chronic-toxicity, and durable transgene expression over first-generation adenoviral vector (FGAd). HDAd vehicles have demonstrated tremendous potential for gene therapy in animal models for inherited diseases, neurodegenerative diseases and cancer etc. Additionally, the large cloning capacity of HdAd, up to 37 kb, permits the delivery of whole genemic loci, multiple transgenes. In this review we characterize the basic features of HdAd and summarize some of their experimental and potential clinical applications both at present and in future.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Adenoviridae
/
Técnicas de Transferencia de Gen
/
Vectores Genéticos
/
Virus Helper
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Wei Sheng Wu Xue Bao
Año:
2009
Tipo del documento:
Article
País de afiliación:
China