A cascade approach to cyclic aminonitrones: reaction discovery, mechanism, and scope.

Sharma, Rojita; Bulger, Paul G; McNevin, Michael; Dormer, Peter G; Ball, Richard G; Streckfuss, Eric; Cuff, James F; Yin, Jingjun; Chen, Cheng-yi

Sharma, Rojita; Bulger, Paul G; McNevin, Michael; Dormer, Peter G; Ball, Richard G; Streckfuss, Eric; Cuff, James F; Yin, Jingjun; Chen, Cheng-yi.

Afiliación

Sharma R; Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA.

Org Lett ; 11(15): 3194-7, 2009 Aug 06.

Article en En | MEDLINE | ID: mdl-19572567

ABSTRACT

ABSTRACT

Treatment of omega-epoxynitriles with hydroxylamine affords cyclic aminonitrones in a single step and with high stereoselectivity. The scope of this novel transformation was explored in a series of examples. The aminonitrone products were shown to be useful substrates for further selective elaboration.

Asunto(s)

Inhibidores de Integrasa VIH/química; Pirimidinonas/química; Cristalografía por Rayos X; Ciclización; Diseño de Fármacos; Inhibidores de Integrasa VIH/síntesis química; Estructura Molecular; Pirimidinonas/síntesis química; Pirrolidinonas/química; Raltegravir Potásico

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinonas / Inhibidores de Integrasa VIH Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2009 Tipo del documento: Article País de afiliación: Estados Unidos

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