The prognostic value of impaired walking distance on long-term outcome in patients with known or suspected peripheral arterial disease.
Eur J Vasc Endovasc Surg
; 38(4): 482-7, 2009 Oct.
Article
en En
| MEDLINE
| ID: mdl-19586784
ABSTRACT
OBJECTIVES:
To assess the predictive value of walking distance after an exercise test on long-term outcome in patients with normal and impaired ankle-brachial index (ABI).DESIGN:
A total of 2191 patients with known or suspected peripheral arterial disease (PAD), who were referred for a single-stage treadmill exercise test to diagnose or evaluate their PAD, were enrolled in an observational study between 1993 and 2006. MATERIALS ANDMETHODS:
They were divided into two groups normal ABI (>or=0.90) and impaired ABI (<0.90). Walking distance was divided into quartiles (no (reference), mild, moderate or severe impairment).RESULTS:
In patients with normal ABI, severe walking distance was, after adjustment, associated with higher mortality risk (hazard ratio (HR) 2.60 (range 1.16-5.78)). In patients with impaired ABI, all walking distance impairment quartiles were associated with higher mortality (mild HR 1.26 (range 0.95-1.67), moderate HR 1.52 (range 1.13-2.05) and severe HR 1.69 (range 1.26-2.27)). Furthermore, comparable associations were observed between all walking distance quartiles, cardiac death or major adverse cerebrovascular and cardiac events.CONCLUSIONS:
Our study illustrated that walking impairment is a strong prognostic indicator of long-term outcome in patients with impaired and normal ABI, which should be a warning sign to physicians to monitor these patients carefully and to provide them optimal treatment.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
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Caminata
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Enfermedades Vasculares Periféricas
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Evaluación de la Discapacidad
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Prueba de Esfuerzo
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur J Vasc Endovasc Surg
Asunto de la revista:
ANGIOLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Países Bajos