[Synthesis, structure and properties of rubomycin derivatives of mono- and oligonucleotides]. / Sintez, struktura i svoistva rubomitsinovykh proizvodnykh mono- i oligonukleotidov.
Bioorg Khim
; 16(10): 1369-78, 1990 Oct.
Article
en Ru
| MEDLINE
| ID: mdl-1964779
ABSTRACT
Daunomycin derivatives of pT(DT) and oligodeoxynucleotides were synthesized using reactive zwitter-ionic 4-N,N-dimethylaminopyridine derivatives of the terminal phosphate group. Daunomycin oligodeoxynucleotide analogues form more stable complementary complexes than the corresponding non-modified oligonucleotides. Both one- and two-dimensional (2D NOESY and 2D COSY) NMR spectra of DT were recorded and the proton signals assigned. From the detected cross-relaxation between H6 of thymidine and H1', H2', H2" of the carbohydrate residue of daunomycin it was concluded that, in DMSO, the DT molecule has a rather stable conformation, apparently due to the stacking interaction between the mononucleotide and daunomycin residues.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Daunorrubicina
Idioma:
Ru
Revista:
Bioorg Khim
Año:
1990
Tipo del documento:
Article