Accessory and main olfactory systems influences on predator odor-induced behavioral and endocrine stress responses in rats.
Behav Brain Res
; 207(1): 70-7, 2010 Feb 11.
Article
en En
| MEDLINE
| ID: mdl-19800371
ABSTRACT
Exposures to predator odors are very effective methods to evoke a variety of stress responses in rodents. We have previously found that ferret odor exposure leads to changes in endocrine hormones (corticosterone and ACTH) and behavior. To distinguish the contributions of the main and accessory olfactory systems in these responses, studies were designed to interfere with these two systems either independently, or simultaneously. Male Sprague-Dawley rats were treated with 10% zinc sulfate (ZnSO(4)), which renders rodents anosmic (unable to smell) while leaving the accessory olfactory areas intact, or saline, in Experiment 1. In Experiment 2, the vomeronasal organs of rats were surgically removed (VNX) to block accessory olfactory processing, while leaving the main olfactory system intact. And in the third experiment both the main and accessory olfactory areas were disrupted by combining the two procedures in the same rats. Neither ZnSO(4) treatment nor VNX alone reliably reduced the increased corticosterone response to ferret odor compared to strawberry odor, but in combination, they did. This suggests that processing through the main or the accessory olfactory system can elicit the endocrine stress response to ferret odor. VNX alone also did not affect the behavioral responses to the ferret odor. ZnSO(4) treatment, alone and in combination with VNX, led to changes in behavior in response to both ferret and strawberry odor, making the behavioral results less clearly interpretable. Overall these studies suggest that both the main and accessory olfactory systems mediate the neuroendocrine response to predator odor.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vías Olfatorias
/
Estrés Psicológico
/
Corticosterona
/
Reacción de Fuga
/
Percepción Olfatoria
Límite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos