Ectopic expression of hC/EBPs in breast tumor cells induces apoptosis.
Mol Cell Biochem
; 337(1-2): 111-8, 2010 Apr.
Article
en En
| MEDLINE
| ID: mdl-19851833
ABSTRACT
CCAAT/enhancer binding proteins (C/EBPs) are a group of transcription factors which have been implicated in cellular proliferation, terminal differentiation, and apoptosis in a variety of tissues including mammary gland. Owing to its role in various cellular functions, inactivation of C/EBP proteins is central to the pathogenesis of many disorders. Recent reports suggest that expression as well as function of C/EBP proteins is deregulated in breast tumors. Although, role of C/EBPs in growth arrest in mammary tissues has been studied in much detail; their role in apoptosis is relatively less explored. In the present study, we have assessed if breast tumors evade apoptosis and grow faster by down regulating and inhibiting the C/EBP proteins, C/EBPalpha in particular. Our data shows that ectopic expression of human C/EBPs in breast tumor cells inhibits proliferation and induces apoptosis which is likely to be associated with caspase dependent pathway.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Apoptosis
/
Proteínas Potenciadoras de Unión a CCAAT
Límite:
Female
/
Humans
Idioma:
En
Revista:
Mol Cell Biochem
Año:
2010
Tipo del documento:
Article
País de afiliación:
India