Gastric acidity inhibitors and the risk of intestinal infections.
Curr Opin Gastroenterol
; 26(1): 31-5, 2010 Jan.
Article
en En
| MEDLINE
| ID: mdl-19907324
ABSTRACT
PURPOSE OF REVIEW We reviewed recent clinical studies performed in adults, children, and neonates exploring the possible association of gastric acidity inhibitors use with intestinal infections. Possible mechanisms have also been reported. RECENT FINDINGS:
Many studies and systematic reviews demonstrate an increased risk of bacterial infection in adults taking acid suppressors. Little evidence is derived from the pediatric population. The use of gastric acidity inhibitors has been associated with systemic infections and necrotizing enterocolitis in preterm infants. Reduced gastric acidity, delayed gastric emptying, increased gastric mucus viscosity, modification in microbiota, and impairment of neutrophils functions, are all conditions determined by gastric acidity blockers that potentially lead to an increased risk of gastrointestinal infections.SUMMARY:
A proper utilization of these drugs, particularly for patients at high risk, is imperative in order to reduce deleterious effects on infection risk and to optimize cost-effectiveness ratio.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Inhibidores de la Bomba de Protones
/
Ácido Gástrico
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Gastroenteritis
/
Antiulcerosos
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Child, preschool
/
Female
/
Humans
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Infant
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Male
/
Newborn
Idioma:
En
Revista:
Curr Opin Gastroenterol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Italia