Formaldehyde dehydrogenase: beyond phase I metabolism.
Toxicol Lett
; 193(1): 1-3, 2010 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-19963048
ABSTRACT
Formaldehyde dehydrogenase, formally Class III alcohol dehydrogenase (ADH3), has recently been discovered to partially regulate nitrosothiol homeostasis by catalyzing the reduction of the endogenous nitrosylating agent S-nitrosoglutathione (GSNO). Several studies have implicated this enzyme, and in particular GSNO reduction, as playing an important role in conditions such as asthma, cardiovascular disease, and immune function. While ADH3 has received considerable attention in the biomedical literature where it is often referred to as GSNO reductase (GSNOR), ADH3-mediated GSNO reduction has received comparatively less attention in the environmental toxicology community. Herein, evidences for a role of ADH3 in cell signaling through thiol homeostasis is highlighted, underscoring that the enzyme functions more broadly than to metabolize formaldehyde.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Aldehído Oxidorreductasas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Toxicol Lett
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos