Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity.
Vaccine
; 27 Suppl 6: G17-20, 2009 Dec 30.
Article
en En
| MEDLINE
| ID: mdl-20006134
ABSTRACT
Originally identified as antiviral substances produced by infected cells, type I interferons (IFN-I) are now known to have a wide range of additional activities within both the innate and adaptive immune response. Here we review properties of IFN-I contributing to their 'natural immune adjuvant' character, and their important role for the function of complete Freund's adjuvant (CFA) and the TLR9-dependent immune adjuvant IC31. We show data to demonstrate that treatment with IFN-I boosts the ability of vaccine/adjuvant combinations to induce peptide-specific CTL in both young and old mice. We view these findings in the perspective of previous clinical applications of IFN-I for vaccination.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Interferón Tipo I
/
Adyuvantes Inmunológicos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Vaccine
Año:
2009
Tipo del documento:
Article
País de afiliación:
Austria