Variants of DENND1B associated with asthma in children.
N Engl J Med
; 362(1): 36-44, 2010 Jan 07.
Article
en En
| MEDLINE
| ID: mdl-20032318
ABSTRACT
BACKGROUND:
Asthma is a complex disease that has genetic and environmental causes. The genetic factors associated with susceptibility to asthma remain largely unknown.METHODS:
We carried out a genomewide association study involving children with asthma. The sample included 793 North American children of European ancestry with persistent asthma who required daily inhaled glucocorticoid therapy and 1988 matched controls (the discovery set). We also tested for genomewide association in an independent cohort of 917 persons of European ancestry who had asthma and 1546 matched controls (the replication set). Finally, we tested for an association between 20 single-nucleotide polymorphisms (SNPs) at chromosome 1q31 and asthma in 1667 North American children of African ancestry who had asthma and 2045 ancestrally matched controls.RESULTS:
In our meta-analysis of all samples from persons of European ancestry, we observed an association, with genomewide significance, between asthma and SNPs at the previously reported locus on 17q21 and an additional eight SNPs at a novel locus on 1q31. The SNP most strongly associated with asthma was rs2786098 (P=8.55x10(-9)). We observed replication of the association of asthma with SNP rs2786098 in the independent series of persons of European ancestry (combined P=9.3x10(-11)). The alternative allele of each of the eight SNPs on chromosome 1q31 was strongly associated with asthma in the children of African ancestry (P=1.6x10(-13) for the comparison across all samples). The 1q31 locus contains the 1q31 locus contains DENND1B, a gene expressed by natural killer cells and dendritic cells. DENND1B protein is predicted to interact with the tumor necrosis factor α receptor [corrected].CONCLUSIONS:
We have identified a locus containing DENND1B on chromosome 1q31.3 that is associated with susceptibility to asthma.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Asma
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Cromosomas Humanos Par 1
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Predisposición Genética a la Enfermedad
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Factores de Intercambio de Guanina Nucleótido
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Polimorfismo de Nucleótido Simple
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Población Blanca
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Proteínas Adaptadoras de Señalización del Receptor del Dominio de Muerte
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Estudio de Asociación del Genoma Completo
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
/
Systematic_reviews
Límite:
Child
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Female
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Humans
/
Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
N Engl J Med
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos