Eradication of cryptosporidium from a defunctionalized colon limb by refeeding stoma effluent.
J Pediatr Surg
; 45(1): E33-6, 2010 Jan.
Article
en En
| MEDLINE
| ID: mdl-20105571
ABSTRACT
Over the last 40 years, cryptosporidium has increasingly been recognized as a cause of acute self-limiting diarrhea in normal hosts. In the immunocompromised patient, cryptosporidium may cause severe illness with prolonged diarrhea and malabsorption. Pharmacologic therapy of cryptosporidium relies on adequate delivery of drug metabolites to the colon. Here we describe a patient who developed toxic megacolon during induction therapy for leukemia, requiring ileostomy formation to proceed with leukemia treatment. Although the megacolon resolved promptly, the resulting isolation of the colon from the fecal stream prevented luminal delivery of active metabolites of anti-protozoal drugs, resulting in persistent cryptosporidiosis. Refeeding of the ileostomy output into the colon effectively eradicated cryptosporidium from the colon and permitted closure of the ileostomy.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ileostomía
/
Colon
/
Enfermedades del Colon
/
Criptosporidiosis
/
Antiprotozoarios
Límite:
Animals
/
Child, preschool
/
Female
/
Humans
Idioma:
En
Revista:
J Pediatr Surg
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos